CAMOSTAT MESYLATE

CAMOSTAT MESYLATE - Names and Identifiers

Name	Camostat mesilate
Synonyms	Camostatemesylate CAMOSTAT MESYLATE Camostat mesilate CAMOSTAT MESILATE ino)-2-oxoethylester,monomethanesulfonate p-(p-guanidinobenzoyloxy)phenylaceticacid,n,n-dimethylcarbamoylmethyleste 4-((4-((aminoiminomethyl)amino)benzoyl)oxy)-benzeneaceticaci2-(dimethylam n,n-dimethylcarbamoylmethyl4-(4-guanidinobenzoyloxy)phenylacetatemethanesul 2-(Dimethylamino)-2-oxoethyl 4-(4-guanidinobenzoyloxy)phenylacetate methanesulphonate N-(diaminomethylidene)-4-[(4-{2-[2-(dimethylamino)-2-oxoethoxy]-2-oxoethyl}phenoxy)carbonyl]anilinium methanesulfonate
CAS	59721-29-8
EINECS	694-565-6
InChI	InChI=1/C20H22N4O5.CH4O3S/c1-24(2)17(25)12-28-18(26)11-13-3-9-16(10-4-13)29-19(27)14-5-7-15(8-6-14)23-20(21)22;1-5(2,3)4/h3-10H,11-12H2,1-2H3,(H4,21,22,23);1H3,(H,2,3,4)

CAMOSTAT MESYLATE - Physico-chemical Properties

Molecular Formula	C21H26N4O8S
Molar Mass	494.52
Melting Point	150-1550C
Boling Point	634.6°C at 760 mmHg
Flash Point	337.6°C
Water Solubility	Soluble in water (100 mM), DMSO (100 mM), and ethanol (<1 mg/ml).
Solubility	H2O: ≥24mg/mL
Vapor Presure	5.22E-16mmHg at 25°C
Appearance	powder
Color	white to tan
Merck	14,1728
Storage Condition	2-8°C
Stability	Stable for 2 years? from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.
In vitro study	Camostat (30 μm) prolongs the attenuation of ENaC function in a human airway epithelial cell model and is reversible with the addition of excess trypsin. Camostat mesilate (500 mM) inhibits the production of TGF-beta by inhibiting Plasmin Activity and reduces the activity of TGF-beta, which blocks the activation of HSCs in vitro. Camostat mesilate (20 mM) has a significant hypoglycemic effect when administered in combination with insulin. In rat small and large intestine homogenates, Camostat mesilate (20 mM) was able to effectively reduce insulin degradation. Camostat mesilate (2 mM) inhibits MCP-1 and TNF-production in activated monocytes. Camostat mesilate (2 mM) inhibits proliferation and MCP-1 production in cultured rat PSCs.
In vivo study	Camostat (100 μg/kg I. T.) was effective in prolonging the attenuation of ENaC activity in the Guinea Pig trachea. In porcine serum-treated rats, Camostat mesilate (1-2 mg/g diet) significantly attenuated the increase in hepatic plasmin and TGF-beta levels, HSC activation, and hepatic fibrosis, there were no significant systemic or local side effects. Camostat mesilate (1 mg/g) prevents pancreatic atrophy and improves pancreatic exocrine function in DBTC-induced rats with chronic pancreatitis. Camostat mesilate (1 mg/g) inhibits chronic inflammation, and DBTC-induced pancreatic fibrosis. Camostat mesilate (1 mg/g) inhibits the development of DBTC-induced pancreatic fibrosis and PSCs activation in the pancreas. In serum and pancreatic tissue, Camostat mesilate (1 mg/g) inhibited mononuclear cell infiltration and inhibited MCP-1 expression. In rats with chronic pancreatitis, Camostat mesilate (100 mg/kg) significantly increased body weight and pancreatic wet weight, and by inhibiting PAP,p8, and cytokine gene expression, significantly inhibits inflammatory changes and fibrosis of the pancreas.

CAMOSTAT MESYLATE - Risk and Safety

Risk Codes	R36/37/38 - Irritating to eyes, respiratory system and skin. R50 - Very Toxic to aquatic organisms
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets.
UN IDs	UN 3077 9 / PGIII
WGK Germany	3
RTECS	CY1571620
Hazard Class	9

CAMOSTAT MESYLATE - Preparation solution concentration reference

	1mg	5mg	10mg
1 mM	2.022 ml	10.111 ml	20.222 ml
5 mM	0.404 ml	2.022 ml	4.044 ml
10 mM	0.202 ml	1.011 ml	2.022 ml
5 mM	0.04 ml	0.202 ml	0.404 ml

Last Update：2024-01-02 23:10:35

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CAMOSTAT MESYLATE

Camostat mesilate

CAS: 59721-29-8

Molecular Formula: C21H26N4O8S

CAMOSTAT MESYLATE - Names and Identifiers

CAMOSTAT MESYLATE - Physico-chemical Properties

CAMOSTAT MESYLATE - Risk and Safety

CAMOSTAT MESYLATE - Preparation solution concentration reference

Supplier List

CAMOSTAT MESYLATE Request for Quotation

Camostat mesilate

CAS: 59721-29-8

Molecular Formula: C21H26N4O8S

CAMOSTAT MESYLATE - Names and Identifiers

CAMOSTAT MESYLATE - Physico-chemical Properties

CAMOSTAT MESYLATE - Risk and Safety

CAMOSTAT MESYLATE - Preparation solution concentration reference

Supplier List

CAMOSTAT MESYLATE